pI: 5.1233 |
Length (AA): 960 |
MW (Da): 107458 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 954 | 1wa5 (C) | 4 | 947 | 24.00 | 0 | 1 | 1.38 | -1.77 |
14 | 960 | 1u6g (C) | 7 | 1203 | 10.00 | 0 | 1 | 0.75 | -0.09 |
8 | 960 | 4zj7 (A) | 5 | 961 | 12.00 | 0 | 1 | 1.00501 | 0.43 |
15 | 954 | 1wa5 (C) | 4 | 947 | 25.00 | 0 | 1 | 1.30147 | -0.62 |
596 | 831 | 4d4e (A) | 12 | 242 | 12.00 | 0.12 | 0.31 | 0.461233 | -1.13 |
598 | 751 | 4u2x (D) | 341 | 505 | 9.00 | 0.36 | 0.09 | 0.262817 | -0.92 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128085)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G46520 | putative cellular apoptosis susceptibility protein / importin-alpha re-exporter |
Babesia bovis | BBOV_II004290 | conserved hypothetical protein |
Brugia malayi | Bm1_27525 | importin beta family protein 5 |
Candida albicans | CaO19.1231 | Chromosome segregation |
Candida albicans | CaO19.1229 | corresponds to N-terminus of S. cerevisiae CSE1 and allelic CaP19.8815 |
Candida albicans | CaO19.1230 | corresponds to middle of S. cerevisiae CSE1 and C-terminus of allelic CaP19.8815 |
Candida albicans | CaO19.8816 | Chromosome segregation |
Caenorhabditis elegans | CELE_Y48G1A.5 | Protein XPO-2 |
Cryptosporidium hominis | Chro.30213 | cellular apoptosis susceptibility gene product |
Cryptosporidium parvum | cgd3_1790 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0291838 | hypothetical protein |
Drosophila melanogaster | Dmel_CG13281 | CAS/CSE1 segregation protein |
Echinococcus granulosus | EgrG_001114600 | exportin 2 |
Entamoeba histolytica | EHI_111750 | importin alpha re-exporter, putative |
Echinococcus multilocularis | EmuJ_001114600 | exportin 2 |
Homo sapiens | ENSG00000124207 | CSE1 chromosome segregation 1-like (yeast) |
Leishmania braziliensis | LbrM.30.3430 | CAS/CSE/importin domain protein, putative |
Leishmania donovani | LdBPK_303440.1 | CAS/CSE/importin domain protein, putative |
Leishmania infantum | LinJ.30.3440 | CAS/CSE/importin domain protein, putative |
Leishmania major | LmjF.30.3390 | CAS/CSE/importin domain protein, putative |
Leishmania mexicana | LmxM.29.3390 | CAS/CSE/importin domain protein, putative |
Loa Loa (eye worm) | LOAG_04783 | importin beta family protein 5 |
Mus musculus | ENSMUSG00000002718 | chromosome segregation 1-like (S. cerevisiae) |
Neospora caninum | NCLIV_008100 | importin-alpha re-exporter, putative |
Oryza sativa | 4327779 | Os01g0235400 |
Plasmodium berghei | PBANKA_0833600 | importin alpha re-exporter, putative |
Plasmodium falciparum | PF3D7_0932800 | importin alpha re-exporter, putative |
Plasmodium knowlesi | PKNH_0731500 | importin alpha re-exporter, putative |
Plasmodium vivax | PVX_087065 | hypothetical protein, conserved |
Plasmodium yoelii | PY04917 | hypothetical protein |
Plasmodium yoelii | PY04916 | ribosomal protein var1, putative |
Saccharomyces cerevisiae | YGL238W | Cse1p |
Schistosoma japonicum | Sjp_0219760 | IPR005043,CAS/CSE, C-terminal,domain-containing |
Schistosoma japonicum | Sjp_0076430 | Exportin-2, putative |
Schistosoma mansoni | Smp_128050 | importin-alpha re-exporter (chromosome segregation 1-like protein) |
Schmidtea mediterranea | mk4.006018.01 | |
Schmidtea mediterranea | mk4.018274.00 | |
Schmidtea mediterranea | mk4.006018.00 | |
Trypanosoma brucei gambiense | Tbg972.6.4560 | importin-alpha re-exporter protein, putative,cellular apoptosis susceptibility protein, putative |
Trypanosoma brucei | Tb927.6.4740 | importin-alpha re-exporter protein, putative |
Trypanosoma congolense | TcIL3000_6_4200 | importin-alpha re-exporter protein, putative |
Trypanosoma cruzi | TcCLB.506835.80 | CAS/CSE/importin domain protein, putative |
Trypanosoma cruzi | TcCLB.506945.30 | CAS/CSE/importin domain protein, putative |
Toxoplasma gondii | TGME49_253730 | importin-beta N-terminal domain-containing protein |
Theileria parva | TP04_0541 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_179110 | importin-alpha re-exporter, putative |
Trichomonas vaginalis | TVAG_115250 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4740 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.4740 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y48G1A.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y48G1A.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y48G1A.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y48G1A.5 | Caenorhabditis elegans | sterile | wormbase |
YGL238W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_253730 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.